If coadministration of CYP3A4 inhibitors with fentanyl is essential, watch patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose adjustments right until stable drug effects are realized.For oral drugs where reductions in bioavailability could cause clinically major effects on its security or efficacy, sepa

Contraindicated in patients with known or suspected gastrointestinal obstruction, together with paralytic ileus; may possibly cause spasm of sphincter of Oddi; opioids may cause will increase in serum amylase; observe patients with biliary tract sickness, such as acute pancreatitis, for worsening symptomsIf coadministration of CYP3A4 inhibitors wit